Milestones

November 2004	Commenced Operations
2005	Developed Surgical Implantation Design
December 2005	Design Freeze Surgical Device
2006	Pre-clinical Studies
Q1 2007	Submitted for Ethical Committee approvals for first implants (Europe)
April 2007	Close Series B $25 million Private Placement Funding
Q2 2007	Received site Ethical Committee and Competent Authority approvals to implant (Europe)
June 2007	Enrolled first patient in European First-in-Man pilot trial
February 2008	Reports preliminary results of FIM study
August 2008	Attained ISO 13485:2003 Certification
March 2009	Completes initial close on $33 million Series C Financing plan
March 2009	Presents chronic hemodynamic data for Synergy micro-pump for chronic heart failure at American College of Cardiology session
July 2009	Awarded a fast-track SBIR grant from NIH to fund the development of a pediatric circulatory support device based on Synergy
September 2009	A total of 27 patients have been implanted with the Synergy device
January 2010	Closes on Series C Financing

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